Effects of gap junction inhibition on 1 contraction waves in the murine small intestine 2 in relation to coupled oscillator theory 3 4 5 6 Sean
نویسنده
چکیده
4 5 6 Sean P Parsons and Jan D Huizinga 7 8 Farncombe Family Digestive Health Research Institute, McMaster University 9 10 11 12 Corresponding Author 13 Sean Parsons 14 Farncombe Institute, 15 McMaster University, 16 1200 Main Street West, 17 HSC 3N5C-H, 18 Hamilton, 19 Ontario L8N 3Z5, 20 Canada. 21 tel: 905 525 9140 x22584 22 fax: 905 522 3454 23 [email protected] 24 25 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (December 11, 2014). doi:10.1152/ajpgi.00338.2014
منابع مشابه
Effects of gap junction inhibition on contraction waves in the murine small intestine in relation to coupled oscillator theory.
Waves of contraction in the small intestine correlate with slow waves generated by the myenteric network of interstitial cells of Cajal. Coupled oscillator theory has been used to explain steplike gradients in the frequency (frequency plateaux) of contraction waves along the length of the small intestine. Inhibition of gap junction coupling between oscillators should lead to predictable effects...
متن کاملAdaptive Fractional-order Control for Synchronization of Two Coupled Neurons in the External Electrical Stimulation
This paper addresses synchronizing two coupled chaotic FitzHugh–Nagumo (FHN) neurons with weakly gap junction under external electrical stimulation (EES). To transmit information among coupled neurons, by generalization of the integer-order FHN equations of the coupled system into the fractional-order in frequency domain using Crone approach, the behavior of each coupled neuron relies on its pa...
متن کاملSpatial Noise in Coupling Strength and Natural Frequency within a Pacemaker Network; Consequences for Development of Intestinal Motor Patterns According to a Weakly Coupled Phase Oscillator Model
Pacemaker activities generated by networks of interstitial cells of Cajal (ICC), in conjunction with the enteric nervous system, orchestrate most motor patterns in the gastrointestinal tract. It was our objective to understand the role of network features of ICC associated with the myenteric plexus (ICC-MP) in the shaping of motor patterns of the small intestine. To that end, a model of weakly ...
متن کاملThe Effect of Cadmium on Apoptotic Genes mRNA Expression of Bax and Bcl-2 in Small Intestine of Rats
Background: Cadmium is a potent toxicant and carcinogenic in human and experimental animals. The evidence indicates that cadmium induces aberrant gene expression, inhibition of DNA damage repair, and apoptosis. In this study, we investigated the effects of IP (intraperitoneal) injection of cadmium on mRNA levels expression of Bcl-2 and Bax genes in rat small intestine. <s...
متن کاملInotropic and chronotropic effects of new cilostamide derivatives on isolated rat atria
Introduction: It was shown in a previous study, that MCPIP, a cilostamide derivative, increased atrial contraction force without changing contraction rate. To improve this property, two new derivatives of cilostamide were synthesized and their effects on PDE3 activity and isolated rat atria contraction were investigated. Methods: The inhibitory effect of each compound on PDE3 enzyme was dete...
متن کامل